After a review of some examples of epistemological dialogue between neurosciences and psychoanalysis (such as the theory of delayed-action effect seen in light of current findings about memory, the activeness of perceptions, dream and different kinds of memory, representations of action and recent discoveries in neuro-imaging, infantile amnesia and the movement from analog to digital communication, the theory of mind in light of projective identification), the author considers the problematic of intersubjectivity in connection with the question of polysensorial synchrony, before concluding with an evocation of some obstacles that stand in the way of this transdisciplinary dialogue.